Sigma-Aldrich NH2 功能化金纳米颗粒，40 nm直径，胺官能化，PEG 3000涂覆，OD 50，分散在H2O中

产品概述

Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.PMID 23009596PMID 21976982PMID 20225865

应用领域

下面列出了其他几种具体应用：因为它们附着在细胞膜上，金纳米粒子可用于靶向给药应用中的细胞和细胞内靶向，也可用于生物分布研究金纳米粒子还可用于光热疗法和放射疗法，还可用于携带siRNA，通过抑制特定的癌症基因来对抗人前列腺癌细胞。PMID 20225865 PMID 16171365

功能化颗粒已广泛用于研究纳米颗粒的细胞摄取和靶向药物递送。

产品特点

A negatively charged siRNA-PEG complex attached to a positively charged GNPs is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.PMID 16171365PMID 20225865 The PEG coating decreases the cytotoxicity and increases effciciency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.

技术规格